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PERSPECTYV
13 October 2019
RESIST-655
13 October 2019

RESIST-430

RESIST-430

NEW GAMMA-PEPTIDE TYPE FOLDAMERS WITH A BROAD SPECTRUM ANTI-INFECTIVE TARGET

Available technology

Desired partnership(s)

  • Licensing

IP

  • Patent

Establishment(s)

  • University of Montpellier
  • CNRS
  • ENSCM

Laboratory(ies)

  • Max Mousseron Institute for Biomolecules (IBMM) - UMR5247

Keywords

  • Bacterial resistance to antibiotics
  • Gram-negative bacteria
  • Gamma-peptides

Context

In recent years, some of the research designed to combat multidrug-resistant bacteria has focused on developing synthetic antimicrobial peptides (AMPs) with lower toxicity and higher activity relative to endogenous natural peptides. AMPs are a promising therapeutic option due to the broad spectrum of antimicrobial activity, low rate of resistance development, and immunomodulatory properties. Most AMPs exhibit rapid broad-spectrum antimicrobial activity. Moreover, they may present anti-fungal, anti-viral, and anti-parasitic activities.

Benefits

The team developed technology to develop synthetic mimes of broad-spectrum AMPs based on a self-structured chemical platform called foldamer. These molecules imitate the amphipathic properties of AMPs and have been shown to be effective against different bacterial strains, including WHO priority bacteria that are weakly hemolytic and stable to proteolysis.

Applications

Antibiotic-resistant Gram-negative bacteria - Other bacteria

AVAILABLE TECHNOLOGY | Bacterial resistance to antibiotics – Gram-negative bacteria – Gamma-peptides

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